Research in the Hodges lab focuses on altered epigenetic function in cancer and other diseases. We use interdisciplinary approaches, including epigenomics, live-cell super-resolution imaging, genome editing, and structural biology, to understand epigenetic systems in disease settings. Our research is especially focused on new technologies, for example, improving cell-culture tumor models, as well as single-cell and single-molecule methods.
The epigenetic landscape is the bridge that connects the genome with its environment. We have taken a special interest in BAF (mSWI/SNF) and PBAF ATP-dependent chromatin remodelers, which are among the most frequently mutated epigenetic regulators in cancer. We aim to improve precision therapies for tumors bearing these mutations by identifying how these complexes alter the intrinsic properties of cells and their interaction with the environment.
We are proud members of Baylor College of Medicine and the MD Anderson Center for Cancer Epigenetics.
We are integrating next-generation sequencing and live-cell microscopy to reveal the biophysical mechanisms central to disease.
Medical research award from Gabrielle's Angel Foundation for Cancer Research, 2018
$2M Faculty Recruitment Award from the Cancer Prevention and Research Institute of Texas, 2017
NextGen Star of the American Association for Cancer Research, 2015
Pathway to Independence Award (K99/R00) from the National Cancer Institute, 2014 (renewed in 2017)